Ashley I Bush Selected Research

Isoflurophate (DFP)

1/2020	The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy.
1/2020	Iron chelation by deferiprone does not rescue the Niemann-Pick Disease Type C1 mouse model.

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Ashley I Bush Research Topics

Disease

186	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 05/2002
48	Cognitive Dysfunction 10/2022 - 10/2004
40	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 04/2004
33	Parkinson Disease (Parkinson's Disease) 12/2022 - 03/2003
21	Amyloid Plaque 10/2022 - 04/2003
16	Schizophrenia (Dementia Praecox) 01/2023 - 08/2008
12	Dementia (Dementias) 04/2022 - 04/2004
10	Huntington Disease (Huntington's Disease) 01/2021 - 03/2007
10	Bipolar Disorder (Manic Depressive Psychosis) 12/2018 - 09/2008
9	Inflammation (Inflammations) 01/2023 - 07/2011
9	Disease Progression 12/2022 - 12/2004
9	Atrophy 01/2020 - 01/2012
8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 03/2024 - 09/2004
7	Tauopathies 09/2023 - 01/2012
7	Iron Overload 01/2023 - 01/2016
7	Parkinsonian Disorders (Parkinsonism) 12/2022 - 01/2012
7	Neuroblastoma 04/2014 - 11/2002
6	Neoplasms (Cancer) 04/2023 - 05/2015
6	Neuroinflammatory Diseases 01/2023 - 11/2012
6	Stroke (Strokes) 10/2021 - 12/2005
6	Mental Disorders (Mental Disorder) 01/2020 - 07/2008
4	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 12/2023 - 03/2014
4	Nervous System Diseases (Neurological Disorders) 08/2023 - 11/2011
4	Body Weight (Weight, Body) 12/2022 - 11/2012
4	Amyloidosis 10/2022 - 12/2004
3	Acute-Phase Reaction 01/2022 - 01/2020
3	Brain Ischemia (Cerebral Ischemia) 01/2022 - 01/2017
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 09/2005
3	Ischemia 10/2021 - 04/2004
3	Proteostasis Deficiencies 01/2021 - 10/2014
3	Frontotemporal Dementia (Semantic Dementia) 11/2020 - 01/2018
3	Necrosis 12/2018 - 05/2009
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2016 - 06/2007
3	Hypoxia (Hypoxemia) 12/2014 - 12/2005
2	Multiple System Atrophy 01/2022 - 11/2021
2	Friedreich Ataxia (Friedreich's Ataxia) 12/2021 - 01/2021
2	Hepatolenticular Degeneration (Wilson's Disease) 11/2021 - 01/2021
2	Synucleinopathies 11/2021 - 01/2016
2	Reperfusion Injury 10/2021 - 01/2021
2	Ischemic Stroke 10/2021 - 01/2017
2	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 01/2021 - 01/2019

Drug/Important Bio-Agent (IBA)

82	IronIBA 08/2023 - 11/2002
62	Amyloid (Amyloid Fibrils)IBA 01/2021 - 04/2003
58	CopperIBA 03/2024 - 10/2002
54	Amyloid beta-PeptidesIBA 08/2023 - 05/2002
51	Proteins (Proteins, Gene)FDA Link 08/2023 - 04/2003
43	MetalsIBA 01/2023 - 11/2002
38	Biomarkers (Surrogate Marker)IBA 11/2022 - 05/2004
36	ZincIBA 01/2023 - 07/2003
22	Peptides (Polypeptides)IBA 01/2020 - 08/2002
15	IonsIBA 01/2018 - 01/2003
13	Apolipoproteins E (ApoE)IBA 11/2022 - 12/2010
12	AntioxidantsIBA 01/2022 - 01/2005
11	Glutathione (Reduced Glutathione)IBA 01/2024 - 07/2008
11	Cysteine (L-Cysteine)FDA Link 12/2018 - 07/2006
10	LipidsIBA 12/2023 - 01/2003
10	CholesterolIBA 12/2023 - 01/2003
10	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 06/2005
10	Ceruloplasmin (Ferroxidase)IBA 01/2021 - 05/2009
9	Trace Elements (Biometals)IBA 10/2017 - 03/2004
9	Acetylcysteine (Siran)FDA LinkGeneric 12/2015 - 07/2008
8	Ferritins (Ferritin)IBA 01/2023 - 12/2008
8	Clioquinol (Vioform)FDA Link 01/2019 - 11/2002
7	tau Proteins (tau Protein)IBA 09/2023 - 11/2010
7	Chelating AgentsIBA 12/2022 - 11/2002
6	Messenger RNA (mRNA)IBA 11/2022 - 08/2002
6	SeleniumIBA 01/2022 - 11/2014
6	EnzymesIBA 01/2022 - 05/2009
5	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2022 - 11/2013
5	DeferiproneIBA 12/2022 - 01/2020
5	Levodopa (L Dopa)FDA LinkGeneric 12/2022 - 05/2013
5	ApolipoproteinsIBA 11/2022 - 12/2010
5	polyglutamineIBA 01/2015 - 03/2007
4	alpha-SynucleinIBA 09/2021 - 01/2016
4	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 01/2014
4	UbiquitinIBA 01/2020 - 01/2014
4	IonophoresIBA 01/2019 - 01/2010
4	Superoxide Dismutase-1IBA 06/2014 - 09/2004
3	RNA (Ribonucleic Acid)IBA 08/2023 - 08/2002
3	Antipsychotic Agents (Antipsychotics)IBA 01/2023 - 09/2008
3	PresenilinsIBA 11/2022 - 03/2011
3	SynucleinsIBA 10/2022 - 03/2016
3	8-hydroxyquinazolin-4(3H)-oneIBA 10/2022 - 01/2017
3	Blood Proteins (Serum Proteins)IBA 01/2022 - 01/2017
3	zinc-binding protein (zinc binding protein)IBA 01/2020 - 01/2013
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018 - 11/2010
3	dityrosineIBA 01/2017 - 01/2004
3	Huntingtin ProteinIBA 01/2017 - 03/2007
3	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2014 - 01/2011
3	Superoxide DismutaseIBA 05/2009 - 10/2002
2	Glucose (Dextrose)FDA LinkGeneric 09/2023 - 05/2009
2	Phenobarbital (Luminal)FDA Link 04/2023 - 07/2013
2	Oxygen (Dioxygen)IBA 01/2023 - 05/2004
2	Lactic Acid (Lactate)FDA LinkGeneric 10/2022 - 01/2015
2	HDL LipoproteinsIBA 10/2022 - 01/2020
2	Selenic AcidIBA 11/2020 - 01/2019
2	Carrier Proteins (Binding Protein)IBA 04/2020 - 11/2012
2	Isoflurophate (DFP)FDA Link 01/2020 - 01/2020
2	Methionine (L-Methionine)FDA Link 01/2020 - 05/2004

Therapy/Procedure

23	Therapeutics 01/2022 - 08/2002